domingo, julho 06, 2008

Corticosteróides em pneumonia adquirida na comunidade - Clique no link para a versao integral do artigo!

Aproveitando o post (enquete) do mês, segue um artigo recém-publicado na Critical Care (em junho 2008) onde abordamos o tema.

Nos parece, a despeito dos guidelines uma área de intensa controvérsia onde novas evidências são bemvindas antes de uma ampla recomendação para o uso de corticosteróides.

Jorge Salluh


The role of corticosteroids in severe community-acquired pneumonia: a systematic review
Jorge IF Salluh1,, Pedro Póvoa, Márcio Soares , Hugo C Castro-Faria-Neto, Fernando A Bozza and Patrícia T Bozza


Introduction

The purpose of this review was to evaluate the impact of corticosteroids on the outcomes of patients with severe community-acquired pneumonia (CAP).

Methods

We performed a systematic MEDLINE, Cochrane database, and CINAHL search (1966 to November 2007) to identify full-text publications that evaluated the use of corticosteroids in CAP.

Results

An initial literature search yielded 109 articles, and 105 studies were excluded after the first analysis. We found four studies eligible for analysis. On the basis of their results, the use of corticosteroids as adjunctive therapy in severe CAP should be categorized as a weak recommendation (two studies) and a strong recommendation (two studies) with either low- or moderate-quality evidence. However, no evidence of adverse outcomes or harm is present in the evaluated studies.

Conclusion

According to the GRADE system, available studies do not support the recommendation of corticosteroids as a standard of care for patients with severe CAP. Further randomized controlled trials with this aim should enroll a larger number of severely ill patients. However, in patients needing corticosteroids, it may be reasonable to conclude that corticosteroid administration is safe in patients with severe infections receiving antimicrobial therapy.