Mortality in ICU patients with bacterial community-acquired pneumonia: when antibiotics are not enough.
Critical Care Department, Pere Virgili Health Institut and CIBER Enfermedades Respiratorias (CIBERES), Joan XXIII University Hospital, Mallafré Guasch 4, 43007, Tarragona, Spain.
BACKGROUND: It remains uncertain why immunocompetent patients with bacterial community-acquired pneumonia (CAP) die, in spite of adequate antibiotics. METHODS: This is a secondary analysis of the CAPUCI database which was a prospective observational multicentre study. Two hundred and twelve immunocompetent patients admitted to 33 Spanish ICUs for CAP were analyzed. Comparisons were made for lifestyle risk factors, comorbidities and severity of illness. ICU mortality was the principal outcome variable. RESULTS: Bacteremic CAP (43.3 vs. 21.1%) and empyema (11.5 vs. 2.2%) were more frequent (P < n =" 122)" n =" 90),">